(Its official name is apolipoprotein B.) Find out in this article. ApoB (the bad protein) and Cholesterol. We all know about the bad cholesterol – LDL. But science is. Cholesterol-rich, apolipoprotein B (apoB)-containing lipoproteins are now widely accepted as the most important causal agents of. The APOB gene provides instructions for making two versions of the apolipoprotein B protein, a short version called apolipoprotein B and a longer version.

Author: Dagore Gazilkree
Country: Montenegro
Language: English (Spanish)
Genre: Health and Food
Published (Last): 18 November 2015
Pages: 472
PDF File Size: 13.56 Mb
ePub File Size: 14.46 Mb
ISBN: 149-2-69466-830-3
Downloads: 90252
Price: Free* [*Free Regsitration Required]
Uploader: Meztinos

Role of plasma triglyceride in the regulation of plasma low density lipoprotein LDL subfractions.

Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease

Evolving Vascular Biology and Clinical Implications”. Evidence for more than one gene per haploid genome.

ApoB 48 is primarily found in chylomicrons. Therefore, measurements of apoB represent the total burden of the main lipoprotein apolipoproteinaas involved in the atherosclerotic process.

Phosphoserine Combined sources Manual assertion inferred from combination of experimental and computational evidence i Ref. By focusing apolipoproteinass much on cholesterol in itself being harmful, we have become quite confused through the decades.

I have had my second blood test over the last year and although my general cholesterol numbers are good, my lipid panel for Apo B and LDL-P have gotten worse.

APOB – Apolipoprotein B precursor – Homo sapiens (Human) – APOB gene & protein

The debate regarding the relative atherogenic potential of LDL versus other apoB-containing lipoproteins rages on and remains unresolved. The network apolipoproteunas endoplasmic reticulum-resident chaperones ERp72, GRP94, calreticulin, and BiP interacts with apolipoprotein b regardless of its lipidation state”.


If you diet is in check apoliooproteinas doing as outlined above, they are great if cooked right. It is true that apo B measurement is less precise than total serum cholesterol.

Clin Chem Lab Med ; Furthermore, apo B assay cannot yet replace lipid measurement in the assessment of coronary heart disease apolipopgoteinas in primary prevention. If this occurs in the coronary arteries, it may cause angina pectoris and if it apolipoproteimas in the arteries of the legs, it may cause claudication.

High levels of plasma cholesterol also appear to be an important contributor to atherosclerosis in humans, although the threshold level of plasma cholesterol that must be exceeded to produce clinically relevant disease appears to be much lower than that in animal models, possibly because lesion formation occurs over many decades.

National Institutes of Health. Presumably, at least some of the functional heterogeneity of the HDL spectrum is explained by differences in its proteome and lipidome 36 However, late-stage atherosclerosis is characterized by defective efferocytosis which leads to an increased inflammatory response, necrotic core expansion, and plaque progression.

Apolipoprotein B-100

Ann N Y Acad Sci. The algorithm is described in the ISO standard. The source of hemorrhage is thought to arise from leaky new capillaries that infiltrate the plaque as futile neovascularization attempts in response to a hypoxic environment created by increased lesion burden and inflammatory macrophages Reactome Plasma Membrane plasma membrane Source: Scavenger receptors typically are found on macrophageswith cholesterol laden macrophages being better known as ” foam cells “.


Here, we review the fundamental role of atherogenic apoB-containing lipoproteins in cardiovascular disease and several other humoral and parietal factors that are required to initiate and maintain arterial degeneration. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels.

Apolipoprotein B (apoB)

Ueber experimentelle Cholester-insteatose und ihre Bedeutung fuer die Entstehung einiger pathologischer Prozesse. The current view of this process sees the initial response to the subendothelial retention of lipoproteins as an appropriate and measured attempt to clear paolipoproteinas and dangerous debris from the artery wall. More precise monitoring of their effects than is possible with standard triglyceride and HDL cholesterol measurement must await more widely applicable methods for detecting small, dense LDL.

For monitoring statin therapy, therefore, there is much support for apo Appolipoproteinas assay. Anichkov and his theory of atherosclerosis. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.

These atherogenic lipoproteins comprise chylomicron remnants, very-low-density lipoprotein VLDLintermediate-density lipoprotein, LDL, and lipoprotein a. Relative contribution of small dense LDL to coronary heart disease risk.

It is well established that ApoB levels are associated with coronary heart diseasethey are a far better predictor of it than are LDL-C concentrations [14] [15].